SCHEMBL12206125

SCHEMBL12206125

Cc1cccc2c(N=C=O)cccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.61
CYP1A2 P05177 6/20 0.52
CYP2A6 P11509 3/20 0.52
TRPA1 O75762 1/20 0.44
ALDH1A1 P00352 6/20 0.40
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
HPGD P15428 5/20 0.37
TDP1 Q9NUW8 4/20 0.37
HSD17B10 Q99714 4/20 0.37
ALOX15 P16050 2/20 0.37
ABCB11 O95342 1/20 0.37
NR3C1 P04150 1/20 0.37
ADRA2A P08913 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
ADRA2C P18825 1/20 0.37
MAOA P21397 1/20 0.37
DRD1 P21728 1/20 0.37
SLC6A4 P31645 1/20 0.37
HTR2B P41595 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11664855 0.88 CYP1A2 (0.52) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL22210 0.87 CYP3A4 (0.62) CYP3A4CYP1A2TRPA1ALDH1A1GABRA1
SCHEMBL29370250 0.87 CYP3A4 (0.62) CYP3A4CYP1A2TRPA1ALDH1A1GABRA1
SCHEMBL31249481 0.82 CYP3A4 (0.53) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL29375242 0.82 CYP3A4 (0.53) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL332723 0.82 CYP3A4 (0.53) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL28831497 0.81 CYP3A4 (0.56) CYP3A4CYP1A2TRPA1ALDH1A1GABRA1
SCHEMBL663362 0.80 CYP3A4 (0.54) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL93192 0.79 CYP3A4 (0.79) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1
SCHEMBL29440559 0.79 CYP3A4 (0.79) CYP3A4CYP1A2CYP2A6TRPA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1096314-B1 Lithographic printing plate precursor FUJIFILM CORP (JP) 2011-10-19 EP disclosed