Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31670505 | 0.93 | ADORA3 (0.35) | KMT2AADORA3ADORA1ADORA2A | |
| SCHEMBL195356 | 0.90 | MAPK1 (0.37) | KMT2AADORA3ADORA1ADORA2A | |
| SCHEMBL31670521 | 0.87 | GLP1R (0.33) | KMT2AADORA3 | |
| SCHEMBL21061380 | 0.84 | GLP1R (0.30) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8256742 | 0.82 | BRD4 (0.38) | EHMT2 | |
| SCHEMBL20838959 | 0.82 | JAK2 (0.38) | KMT2AADORA3ADORA1ADORA2AMAPT | |
| SCHEMBL21098222 | 0.82 | — | — | |
| SCHEMBL20838961 | 0.81 | EHMT2 (0.31) | EHMT2TDP1 | |
| SCHEMBL20838972 | 0.81 | PDE4D (0.34) | — | |
| SCHEMBL516223 | 0.79 | TDP1 (0.36) | KMT2ANPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380891-A1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |