Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122018 | 1.00 | ELANE (0.58) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL1154897 | 0.89 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122017 | 0.89 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122114 | 0.89 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL2617947 | 0.87 | ELANE (0.72) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL123977 | 0.86 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122770 | 0.86 | ELANE (0.75) | ELANECYP2C9 | |
| SCHEMBL124338 | 0.85 | ELANE (0.64) | ELANECYP2C9 | |
| SCHEMBL126645 | 0.85 | ELANE (0.64) | ELANECYP2C9 | |
| SCHEMBL122466 | 0.85 | ELANE (0.77) | ELANECYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417112-B1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTITUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER IP GMBH (DE) | 2014-07-09 | — | — | EP | disclosed |
| EP-2234985-B1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | Bayer Pharma AG (DE) | 2012-03-07 | — | — | EP | disclosed |
| EP-2417112-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTITUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010115548-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTITUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-10-14 | — | — | WO | disclosed |