Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122114 | 1.00 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122017 | 1.00 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL2617947 | 0.93 | ELANE (0.72) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL123977 | 0.92 | ELANE (0.62) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122770 | 0.89 | ELANE (0.75) | ELANECYP2C9 | |
| SCHEMBL122115 | 0.89 | ELANE (0.58) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL122018 | 0.89 | ELANE (0.58) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL2617950 | 0.89 | ELANE (0.69) | ELANECYP2C9CYP2C8CYP2C19ADRB1 | |
| SCHEMBL1134157 | 0.87 | ELANE (0.78) | ELANECYP2C9CYP2C8CYP2C19 | |
| SCHEMBL15473037 | 0.86 | ELANE (0.46) | ELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174997-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | PH PHARMA CO., LTD. (KR) | 2015-02-12 | — | — | US | disclosed |
| US-8889700-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20140045802-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-13 | — | — | US | disclosed |
| US-8288402-B2 | 4-(4-cyano-2-thioaryl)dihydropyrimidinones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-19 | — | — | US | disclosed |
| US-20110034433-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045802-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | TNNI3, TNNT2, PC | ELANE 1598/4885CYP2C9 582/4885CYP2C8 384/4885 |
| US-20120094968-A1 | SULFONIC AMIDE AND SULFOXIMINE-SUBSTTTUTED DIARYL-DIHYDROPYRIMIDINONES AND USAGE THEREOF | STS, SQOR, TST | ELANE 2343/4885CYP2C9 2026/4885CYP2C8 906/4885 |
| US-20150045344-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | TNNI3, TNNT2, PC | ELANE 1850/4885CYP2C9 581/4885CYP2C8 413/4885 |
| US-20110034433-A1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE | TNNI3, TNNT2, PC | ELANE 1598/4885CYP2C9 582/4885CYP2C8 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.