⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15883840 | 1.00 | — | — | |
| SCHEMBL195346 | 1.00 | — | — | |
| SCHEMBL13263355 | 0.86 | — | — | |
| SCHEMBL6439082 | 0.86 | — | — | |
| SCHEMBL4209646 | 0.85 | ADH1B (0.31) | — | |
| SCHEMBL12291920 | 0.79 | ADH1B (0.32) | — | |
| SCHEMBL24377731 | 0.75 | ADH1B (0.30) | — | |
| SCHEMBL5372257 | 0.75 | TP53 (0.30) | — | |
| SCHEMBL1766607 | 0.75 | — | — | |
| SCHEMBL4058988 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409952-B2 | Peptide-compound cyclization method | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-08-09 | — | — | US | disclosed |
| WO-2016054432-A1 | NON-IONIC AND THERMORESPONSIVE DIBLOCK COPOLYPEPTIDE HYDROGELS FOR DELIVERY OF MOLECULES AND CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-07 | — | — | WO | disclosed |
| US-9062007-B2 | Cyclic amide BACE-1 inhibitors having a benzamide substituent | MERCK SHARP & DOHME CORP. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9056862-B2 | Thioxothiazolidine derivative having Ras function inhibitory effect | NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) | 2015-06-16 | — | — | US | disclosed |
| US-20140194412-A1 | THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT | KNC LABORATORIES CO., LTD. (JP) | 2014-07-10 | — | — | US | disclosed |
| US-20140128361-A1 | CYCLIC AMIDE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-8623867-B2 | Cyclic amine BACE-1 inhibitors having a benzamide substituent | MERCK SHARP & DOHME CORP. (US) | 2014-01-07 | — | — | US | disclosed |
| US-20130004518-A1 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | Merck, Sharp & Dohme Corp. (US) | 2013-01-03 | — | — | US | disclosed |
| EP-2508611-A1 | Process for production of triprenyl phenol compounds | Tokyo University of Agriculture and Technology TLO Co., Ltd. (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-8039641-B2 | Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates | AMURA THERAPEUTICS LIMITED (GB) | 2011-10-18 | — | — | US | disclosed |
| US-20090247471-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LTD. (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090192322-A1 | Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates | AMURA THERAPEUTICS LIMITED (GB) | 2009-07-30 | — | — | US | disclosed |
| US-7425562-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LTD. (GB) | 2008-09-16 | — | — | US | disclosed |