Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12083728 | 0.82 | USP2 (0.45) | ALDH1A1USP2MAPK1CYP2D6SMN1; SMN2 | |
| SCHEMBL12216937 | 0.81 | KDM4E (0.41) | ALDH1A1USP2LMNATP53KMT2A | |
| SCHEMBL18751386 | 0.77 | SMN1; SMN2 (0.40) | ALDH1A1USP2MAPK1CYP1A2CHRM2 | |
| SCHEMBL6834405 | 0.75 | USP2 (0.39) | ALDH1A1USP2MAPK1CYP2D6SMN1; SMN2 | |
| SCHEMBL12349250 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1THRB | |
| SCHEMBL6834420 | 0.74 | USP2 (0.35) | ALDH1A1USP2MAPK1CYP1A2CHRM2 | |
| SCHEMBL12349177 | 0.74 | POLB (0.40) | ALDH1A1CYP2D6SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11911617 | 0.73 | USP2 (0.47) | ALDH1A1USP2MAPK1CYP1A2CHRM2 | |
| SCHEMBL14759894 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KMT2ATHRB | |
| SCHEMBL28372931 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10653780-B2 | Amino lipids and methods for the delivery of nucleic acids | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2020-05-19 | — | — | US | disclosed |
| EP-3225621-A1 | IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | Arbutus Biopharma Corporation (CA) | 2017-10-04 | — | — | EP | disclosed |
| EP-2743265-B1 | Improved amino lipids and methods for the delivery of nucleic acids | ARBUTUS BIOPHARMA CORP (CA) | 2017-03-15 | — | — | EP | disclosed |
| US-20160095924-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2016-04-07 | — | — | US | disclosed |
| US-20160095924-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2016-04-07 | — | — | US | disclosed |
| US-9139554-B2 | Amino lipids and methods for the delivery of nucleic acids | TEKMIRA PHARMACEUTICALS CORPORATION (CA) | 2015-09-22 | — | — | US | disclosed |
| US-9139554-B2 | Amino lipids and methods for the delivery of nucleic acids | TEKMIRA PHARMACEUTICALS CORPORATION (CA) | 2015-09-22 | — | — | US | disclosed |
| US-20110256175-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-20 | — | — | US | disclosed |
| US-20110256175-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160095924-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | NSUN3, SARNP, LDLR | ALDH1A1 4284/4885USP2 2383/4885MAPK1 4562/4885 |
| US-10653780-B2 | Amino lipids and methods for the delivery of nucleic acids | NSUN3, SARNP, LDLR | ALDH1A1 4284/4885USP2 2383/4885MAPK1 4562/4885 |
| US-20110256175-A1 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS | NSUN3, SARNP, LDLR | ALDH1A1 4284/4885USP2 2383/4885MAPK1 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.