Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 7/20 | 0.35 |
| ▸ | GCK | P35557 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12197611 | 0.75 | LRRK2 (0.42) | LRRK2GCKPIK3CAMAPK1MAPK8 | |
| SCHEMBL16120490 | 0.75 | LRRK2 (0.42) | LRRK2IGF1RGCKPIK3CAMAPK1 | |
| SCHEMBL16120663 | 0.74 | HTT (0.44) | LRRK2GCKPIK3CAMAPK1MAPK8 | |
| SCHEMBL17709583 | 0.70 | LRRK2 (0.38) | LRRK2GCKPIK3CAMAPK1MAPK8 | |
| SCHEMBL16120666 | 0.70 | LRRK2 (0.38) | LRRK2GCKPIK3CAMAPK1MAPK8 | |
| SCHEMBL20909971 | 0.69 | SYK (0.41) | LRRK2PIK3CAMAPK1MAPK8MAPK9 | |
| SCHEMBL31397754 | 0.68 | LRRK2 (0.41) | LRRK2IGF1RGCKPIK3CAMAPK1 | |
| SCHEMBL2499014 | 0.68 | SYK (0.62) | MAPK1SYK | |
| SCHEMBL12223691 | 0.68 | HASPIN (0.32) | — | |
| SCHEMBL13174243 | 0.68 | MEN1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110245229-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES | MSD K.K. (JP) | 2011-10-06 | — | — | US | disclosed |
| WO-2010067888-A1 | DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245229-A1 | DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES | WEE2, WEE1, CDKL1 | LRRK2 691/4885IGF1R 202/4885GCK 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.