SCHEMBL12230516

SCHEMBL12230516

C(#CB1Oc2cc3ccccc3cc2O1)B1Oc2cc3ccccc3cc2O1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.36
CASP6 P55212 1/20 0.36
ALDH1A1 P00352 4/20 0.34
HSD17B10 Q99714 4/20 0.34
CYP3A4 P08684 3/20 0.34
HIF1A Q16665 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
CASP1 P29466 2/20 0.34
CASP7 P55210 2/20 0.34
ALOX15 P16050 1/20 0.34
HBB P68871 1/20 0.34
CYP2A6 P11509 6/20 0.32
CYP1A2 P05177 4/20 0.32
PDPK1 O15530 1/20 0.32
NQO2 P16083 1/20 0.32
ALOX12 P18054 1/20 0.32
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12230517 0.79 ABCG2 (0.41) TSHR
SCHEMBL14028769 0.73 CYP2A6 (0.38) POLBCASP6ALDH1A1HSD17B10CYP3A4
SCHEMBL3077123 0.68 CYP1A2 (0.39) POLBCASP6ALDH1A1HSD17B10CYP3A4
SCHEMBL2746875 0.68 CYP2A6 (0.34) POLBCASP6TDP1CYP2A6CYP1A2
SCHEMBL903605 0.68 AHR (0.46) POLBCASP6ALDH1A1HSD17B10CYP3A4
SCHEMBL16779994 0.68 AHR (0.46) POLBCASP6ALDH1A1HSD17B10CYP3A4
SCHEMBL1840582 0.67 ABCG2 (0.60) ALDH1A1HSD17B10CYP3A4CYP2D6CYP2C9
SCHEMBL3798534 0.66 ALDH1A1 (0.61) ALDH1A1HSD17B10CYP3A4HIF1ATDP1
Benz(B)Anthracene SCHEMBL17849077 0.66 ALDH1A1 (0.61) ALDH1A1HSD17B10CYP3A4HIF1ATDP1
Benz(B)Anthracene SCHEMBL22352910 0.66 ALDH1A1 (0.61) ALDH1A1HSD17B10CYP3A4HIF1ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8288497-B2 Synthesis of poly-(P-aryleneethynylene)s in neat water under aerobic conditions THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2012-10-16 US disclosed
US-8288497-B2 Synthesis of poly-(P-aryleneethynylene)s in neat water under aerobic conditions THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2012-10-16 US disclosed
US-20110257356-A1 Synthesis of Poly-(P-Aryleneethynylene)s in Neat Water Under Aerobic Conditions THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2011-10-20 US disclosed
US-20110257356-A1 Synthesis of Poly-(P-Aryleneethynylene)s in Neat Water Under Aerobic Conditions THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2011-10-20 US disclosed
US-20090326150-A1 SYNTHESIS OF POLY-(P-ARYLENEETHYNYLENE)S IN NEAT WATER UNDER AEROBIC CONDIT THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2009-12-31 US disclosed
US-20090326150-A1 SYNTHESIS OF POLY-(P-ARYLENEETHYNYLENE)S IN NEAT WATER UNDER AEROBIC CONDIT THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2009-12-31 US disclosed