Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 10/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122319 | 0.84 | BTK (0.69) | BTKTNK2PIK3CD | |
| SCHEMBL123466 | 0.82 | BTK (0.70) | BTKTNK2PIK3CD | |
| SCHEMBL122890 | 0.75 | BTK (0.60) | BTKTNK2RIPK1 | |
| SCHEMBL123014 | 0.72 | BTK (0.68) | BTKTNK2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL122380 | 0.72 | BTK (0.53) | BTKTNK2FYNRIPK1 | |
| SCHEMBL122566 | 0.71 | BTK (0.94) | BTKTNK2 | |
| SCHEMBL16332956 | 0.70 | BTK (0.75) | BTKTNK2PIK3CD | |
| SCHEMBL121239 | 0.70 | BTK (0.69) | BTKTNK2 | |
| SCHEMBL122280 | 0.70 | BTK (1.00) | BTKTNK2 | |
| SCHEMBL121733 | 0.70 | BTK (0.54) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-A1 | PYRROLOTRIAZINE COMPOUNDS | Locus Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |