Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.70 |
| ▸ | TNK2 | Q07912 | 15/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122566 | 0.84 | BTK (0.94) | BTKTNK2 | |
| SCHEMBL16332956 | 0.84 | BTK (0.75) | BTKTNK2PIK3CD | |
| SCHEMBL123014 | 0.84 | BTK (0.68) | BTKTNK2PIK3CDAXLMERTK | |
| SCHEMBL122280 | 0.82 | BTK (1.00) | BTKTNK2 | |
| SCHEMBL122320 | 0.82 | BTK (0.54) | BTKTNK2PIK3CD | |
| SCHEMBL175374 | 0.80 | BTK (0.69) | BTKTNK2 | |
| SCHEMBL124553 | 0.75 | BTK (0.69) | BTKTNK2PIK3CD | |
| SCHEMBL120432 | 0.75 | BTK (0.66) | BTKTNK2 | |
| SCHEMBL120433 | 0.75 | BTK (0.66) | BTKTNK2 | |
| SCHEMBL170027 | 0.74 | BTK (0.61) | BTKTNK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424368-A1 | PYRROLOTRIAZINE COMPOUNDS | Locus Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |