Sugi Predict

Sugi Predict / Compounds / SCHEMBL12236702

SCHEMBL12236702

SCHEMBL12236702

Nc1ccc(N2CCO[C@@H](CO)C2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 1/20 0.49
▸ ADORA1 P30542 1/20 0.49
▸ SYK P43405 3/20 0.47
▸ CD63 P08962 1/20 0.47
▸ PDK1 Q15118 1/20 0.41
▸ CHEK1 O14757 1/20 0.40
▸ MAPT P10636 4/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ GAA P10253 3/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ HTT P42858 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ USP2 O75604 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ THRB P10828 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ RECQL P46063 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12197968 1.00 ADORA2A (0.49) ADORA2AADORA1SYKCD63PDK1
SCHEMBL15650764 1.00 ADORA2A (0.49) ADORA2AADORA1SYKCD63PDK1
SCHEMBL12235945 0.88 ADORA2A (0.39) ADORA2AADORA1SYKCD63MAPT
SCHEMBL17076716 0.88 ADORA2A (0.39) ADORA2AADORA1SYKCD63MAPT
SCHEMBL21204465 0.84 ADORA2A (0.43) ADORA2AADORA1SYKCD63PDK1
SCHEMBL17665057 0.84 ADORA2A (0.43) ADORA2AADORA1SYKCD63PDK1
SCHEMBL31276803 0.84 ADORA2A (0.43) ADORA2AADORA1SYKCD63PDK1
SCHEMBL17665175 0.84 ADORA2A (0.43) ADORA2AADORA1SYKCD63PDK1
SCHEMBL16440172 0.84 ADORA2A (0.43) ADORA2AADORA1SYKCD63PDK1
SCHEMBL31438074 0.84 MAPT (0.46) ADORA2AADORA1SYKCD63MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12263163-B2 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as a Syk inhibitor Kronos Bio, Inc. (US) 2025-04-01 — — US disclosed
US-20230158023-A1 CRYSTALLINE SUCCINATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE GILEAD SCIENCES, INC. 2023-05-25 — — US disclosed
US-20230158023-A1 CRYSTALLINE SUCCINATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE GILEAD SCIENCES, INC. 2023-05-25 — — US disclosed
US-20230158023-A1 CRYSTALLINE SUCCINATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE GILEAD SCIENCES, INC. 2023-05-25 — — US disclosed
US-11517570-B2 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine Kronos Bio, Inc. (US) 2022-12-06 — — US disclosed
US-11517570-B2 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine Kronos Bio, Inc. (US) 2022-12-06 — — US disclosed
EP-3342773-B9 SYK INHIBITORS KRONOS BIO INC (US) 2021-06-09 — — EP disclosed
EP-3342773-B9 SYK INHIBITORS KRONOS BIO INC (US) 2021-06-09 — — EP disclosed
EP-3517536-B1 AMINOTRIAZINE DERIVATIVES USEFUL AS TANK-BINDING KINASE INHIBITOR COMPOUNDS GILEAD SCIENCES INC (US) 2021-05-05 — — EP disclosed
US-20210060011-A1 CRYSTALLINE MONOMESYLATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE Kronos Bio, Inc. 2021-03-04 — — US disclosed
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-24 — — US disclosed
US-20150259340-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2015-09-17 — — US disclosed
WO-2015100217-A1 SYK INHIBITORS GILEAD SCIENCES, INC. (US) 2015-07-02 — — WO disclosed
WO-2015100217-A1 SYK INHIBITORS GILEAD SCIENCES, INC. (US) 2015-07-02 — — WO disclosed
US-20150175616-A1 SYK INHIBITORS Kronos Bio, Inc. 2015-06-25 — — US disclosed
US-20150175616-A1 SYK INHIBITORS Kronos Bio, Inc. 2015-06-25 — — US disclosed
US-20150175616-A1 SYK INHIBITORS Kronos Bio, Inc. 2015-06-25 — — US disclosed
WO-2014060113-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
US-20110251177-A1 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES RIGEL PHARMACEUTICALS, INC. (US) 2011-10-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11517570-B2 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine SYK, LCK, LYN ADORA2A 4200/4885ADORA1 4105/4885SYK 1/4885
US-20150259340-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK ADORA2A 3806/4885ADORA1 3688/4885SYK 11/4885
US-20150266882-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS LRRK2, MYLK2, MYLK ADORA2A 2295/4885ADORA1 2322/4885SYK 9/4885
US-20110251177-A1 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES TYMP, DPYD, TYMS ADORA2A 69/4885ADORA1 315/4885SYK 1871/4885
US-20230158023-A1 CRYSTALLINE SUCCINATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE SYK, LCK, LYN ADORA2A 4200/4885ADORA1 4105/4885SYK 1/4885
US-12263163-B2 Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as a Syk inhibitor SYK, LCK, LYN ADORA2A 4307/4885ADORA1 4259/4885SYK 1/4885
US-20150175616-A1 SYK INHIBITORS SYK, BTK, LYN ADORA2A 2992/4885ADORA1 2554/4885SYK 1/4885
US-20210060011-A1 CRYSTALLINE MONOMESYLATE SALT OF 6-(6-AMINOPYRAZIN-2-YL)-N-(4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PHENYL)IMIDAZO[1,2-a]PYRAZIN-8-AMINE SYK, LYN, BTK ADORA2A 2670/4885ADORA1 2535/4885SYK 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.