MYLK

Myosin light chain kinase, smooth muscle · Q15746 · MYLK on Sugi Atlas →

16,545 patent compounds predicted against MYLK, 12,143 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL234917	0.43	5/20
Lestaurtinib (SCHEMBL730955)	1.00	4/20
Fasudil (SCHEMBL4674)	1.00	3/20
Fasudil (SCHEMBL317082)	0.98	3/20
Fasudil (SCHEMBL599053)	0.98	3/20
Fasudil (SCHEMBL678615)	0.98	3/20
Hydroxyfasudil (SCHEMBL123699)	0.73	3/20
SCHEMBL566377	0.71	3/20
Hydrochloric Acid (SCHEMBL574657)	0.70	3/20
SCHEMBL567383	0.69	3/20
Hydrochloric Acid (SCHEMBL566393)	0.68	3/20
SCHEMBL568042	0.55	3/20
Hydrochloric Acid (SCHEMBL568132)	0.54	3/20
SCHEMBL568043	0.47	3/20
SCHEMBL92545	0.41	3/20
Hydrochloric Acid (SCHEMBL189869)	0.41	3/20
SCHEMBL124161	1.00	2/20
SCHEMBL226317	1.00	2/20
Hydrochloric Acid (SCHEMBL507871)	0.98	2/20
Hydrochloric Acid (SCHEMBL507872)	0.98	2/20

Clinical trials — most relevant to MYLK by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cardiovascular Effects of Chronic Sildenafil in Men With Type 2 Diabetes	PHASE4	COMPLETED
Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids)	PHASE2	COMPLETED
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy	PHASE2	RECRUITING
COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure	PHASE2	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL	EARLY_PHASE1	UNKNOWN
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Genetic Analysis of African-Americans With High Blood Pressure	nan	COMPLETED
Effects of Whole Body Vibration and Resistance Exercise on Carotis Intima Media and Muscle Architecture in Hypertension	nan	COMPLETED
LIPCAR, Cuproptosis, and Α-SMA in the Pathogenesis of AMI and Remodeling	nan	NOT_YET_RECRUITING
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Airway Smooth Muscle and Asthma Severity	nan	COMPLETED
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill	nan	UNKNOWN
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction	nan	COMPLETED
Identification of Novel Molecular Markers for Vasospasm	nan	COMPLETED
The Effect of a Diabetic- and a Kidney-like Environment on Gene and Protein Expression in Cultured EC and SMC	nan	UNKNOWN
Clinical and Angiographic Outcomes With Hyperglycemic Control Post PCI	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
A Pilot Study of Biomarkers for Spinal Muscular Atrophy	nan	COMPLETED
Molecular Mechanism Study of Uterine Sarcoma	nan	UNKNOWN
Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease	nan	COMPLETED
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma	nan	UNKNOWN
Effectiveness of Kaltenborn Mobilizations Versus Muscle Energy Technique in Adhesive Capsulitis.	nan	UNKNOWN
Biomarkers in the Diagnosis and Prognosis of NAFLD	nan	RECRUITING
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis	nan	RECRUITING
3D-Microscopic Muscle Architecture in Cerebral Palsy	nan	RECRUITING
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium	nan	COMPLETED
Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope	nan	RECRUITING
Fat Induced Insulin Resistance and Atherosclerosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MYLK binder may also engage these)

Protein	Name	Similarity
Q6PDN3	—	1.000	Q6PDN3 →
P11799	—	0.999	P11799 →
Q6TXD4	—	0.983	Q6TXD4 →
O54967	—	0.983	O54967 →
O70405	—	0.983	O70405 →
Q696W0	—	0.982	Q696W0 →
Q6XZF7	—	0.982	Q6XZF7 →
Q91X43	—	0.982	Q91X43 →
Q8VDP4	—	0.982	Q8VDP4 →
Q8K330	—	0.981	Q8K330 →
Q8N4X5	—	0.981	Q8N4X5 →
Q3UJB9	—	0.981	Q3UJB9 →
A5D7F8	—	0.981	A5D7F8 →
Q498M5	—	0.981	Q498M5 →
Q62407	—	0.981	Q62407 →
A1X157	—	0.980	A1X157 →
Q17R10	—	0.980	Q17R10 →
Q8BZT2	—	0.980	Q8BZT2 →
M0R4F8	—	0.980	M0R4F8 →
Q09YJ3	—	0.980	Q09YJ3 →
Q2IBF8	—	0.980	Q2IBF8 →
P0C5E3	—	0.980	P0C5E3 →
Q3ULB5	—	0.979	Q3ULB5 →
Q09YG9	—	0.979	Q09YG9 →
Q07E15	—	0.979	Q07E15 →
Q6PFD6	—	0.979	Q6PFD6 →
Q2IBE6	—	0.979	Q2IBE6 →
Q8BGT6	—	0.979	Q8BGT6 →
Q3UIZ8	—	0.979	Q3UIZ8 →
O88599	—	0.979	O88599 →