Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | PDE2A | O00408 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.48 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12237798 | 0.93 | L3MBTL3 (0.54) | HCRTR1HCRTR2PDE2APIK3CAMTOR | |
| SCHEMBL280261 | 0.79 | HCRTR1 (0.53) | HCRTR1HCRTR2PDE2AMAP3K12GAA | |
| SCHEMBL20094149 | 0.78 | L3MBTL3 (0.55) | TLR9TLR8TLR7L3MBTL3HSD11B1 | |
| SCHEMBL10293595 | 0.77 | MEN1 (0.67) | HCRTR1HCRTR2PDE2AMAP3K12LMNA | |
| SCHEMBL11961208 | 0.77 | L3MBTL3 (0.63) | HCRTR1HCRTR2PIK3CAMTORL3MBTL3 | |
| SCHEMBL12237837 | 0.76 | L3MBTL3 (0.71) | L3MBTL3HSD11B1LMNAHPGD | |
| SCHEMBL12237840 | 0.76 | L3MBTL3 (0.71) | L3MBTL3HSD11B1LMNAHPGD | |
| SCHEMBL10195734 | 0.76 | L3MBTL3 (0.71) | L3MBTL3HSD11B1LMNAHPGD | |
| SCHEMBL4697556 | 0.75 | L3MBTL3 (0.50) | PIK3CAMTORL3MBTL3 | |
| SCHEMBL1447788 | 0.75 | L3MBTL3 (0.50) | PIK3CAMTORL3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853420-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-8853420-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20110263565-A1 | COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| US-20110263565-A1 | COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-27 | — | — | US | disclosed |
| WO-2010012747-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263565-A1 | COMPOUNDS | MKI67, CCNA1, CCNT1 | HCRTR1 889/4885HCRTR2 2226/4885PDE2A 2336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.