Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087941 | 0.82 | PARP1 (0.63) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| SCHEMBL31220894 | 0.82 | PARP1 (0.63) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| SCHEMBL12240067 | 0.81 | RXFP1 (0.60) | PARP1RXFP1HSP90AA1SIGMAR1HRH4 | |
| SCHEMBL1223521 | 0.79 | PARP1 (0.49) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL2849329 | 0.78 | KDM4E (0.58) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| SCHEMBL938535 | 0.77 | HCRTR1 (0.50) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| SCHEMBL31568105 | 0.77 | RXFP1 (0.63) | PARP1RXFP1HSP90AA1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL224268 | 0.76 | HCRTR1 (0.49) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL20524495 | 0.75 | PARP1 (0.48) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 | |
| SCHEMBL937498 | 0.74 | GPR183 (0.50) | PARP1RXFP1TDO2HSP90AA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039463-B2 | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-10-18 | — | — | US | disclosed |
| US-20090239848-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239848-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE | SCD, SCD5, FADS2 | PARP1 1257/4885RXFP1 4083/4885TDO2 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.