Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | STIM1 | Q13586 | 4/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.53 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156032 | 0.90 | STIM1 (0.51) | RAB9ASMN1; SMN2TP53TSHRNFKB1 | |
| SCHEMBL12241544 | 0.89 | STIM1 (0.54) | RAB9ASMN1; SMN2TP53TSHRNFKB1 | |
| SCHEMBL12155519 | 0.89 | STIM1 (0.57) | RAB9ASMN1; SMN2TSHRSTIM1ORAI1 | |
| SCHEMBL12156029 | 0.89 | STIM1 (0.50) | RAB9ASMN1; SMN2TP53TSHRNFKB1 | |
| SCHEMBL12241456 | 0.89 | STIM1 (0.55) | RAB9ASMN1; SMN2TSHRSTIM1ORAI1 | |
| SCHEMBL17049614 | 0.89 | STIM1 (0.50) | RAB9ASMN1; SMN2TP53TSHRNFKB1 | |
| SCHEMBL17049821 | 0.88 | DEGS1 (0.53) | STIM1ORAI1ORAI2DEGS1F10 | |
| SCHEMBL12241422 | 0.88 | RAB9A (0.54) | RAB9ASMN1; SMN2TP53STIM1ORAI1 | |
| SCHEMBL17805382 | 0.85 | STIM1 (0.51) | RAB9ASMN1; SMN2TP53TSHRSTIM1 | |
| SCHEMBL12155829 | 0.84 | STIM1 (0.58) | RAB9ASTIM1ORAI1ORAI2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150322012-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2015-11-12 | — | — | US | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-8980629-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322012-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | RAB9A 1174/4885SMN1; SMN2 854/4885TP53 2681/4885 |
| US-20110263612-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | RAB9A 1174/4885SMN1; SMN2 854/4885TP53 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.