Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25909437 | 0.90 | TMPRSS2 (0.37) | TMPRSS2PIK3CD | |
| SCHEMBL22142989 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL26326095 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL26878544 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL12393281 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL18605972 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL26319768 | 0.89 | TMPRSS2 (0.44) | TMPRSS2 | |
| SCHEMBL25187142 | 0.89 | TMPRSS2 (0.39) | TMPRSS2PIK3CD | |
| SCHEMBL12243202 | 0.89 | TMPRSS2 (0.39) | TMPRSS2PIK3CD | |
| SCHEMBL12243209 | 0.89 | TMPRSS2 (0.34) | TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023600-B2 | Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs | GILEAD SCIENCES, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20110230654-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023600-B2 | Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs | PNP, TYMP, CDA | TMPRSS2 4714/4885PRMT5 1367/4885WDR77 2418/4885 |
| US-20110230654-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS | PNP, TYMP, CDA | TMPRSS2 4673/4885PRMT5 1560/4885WDR77 2455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.