Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3966683 | 1.00 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL1005659 | 1.00 | — | — | |
| Piperazine SCHEMBL1005658 | 1.00 | HIF1A (0.86) | — | |
| Bromide SCHEMBL6017046 | 1.00 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL28043140 | 0.94 | — | — | |
| Bromide SCHEMBL12004053 | 0.94 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL5370035 | 0.94 | HIF1A (0.75) | — | |
| Piperazine SCHEMBL5370033 | 0.94 | — | — | |
| Piperazine SCHEMBL5380983 | 0.94 | — | — | |
| SCHEMBL7052601 | 0.93 | HIF1A (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118510295-A | Structure for perovskite battery, perovskite single-junction battery and laminated battery and preparation method thereof | 隆基绿能科技股份有限公司 | 2024-08-16 | — | — | CN | claimed |
| WO-2024031051-A1 | LIPIDS FOR NUCLEIC ACID DELIVERY | Life Technologies Corporation (US) | 2024-02-08 | — | — | WO | claimed |
| CN-117082881-A | Perovskite solar cell post-treated by piperazine hydrobromide and preparation method thereof | 四川大学 | 2023-11-17 | — | — | CN | claimed |
| CN-108341793-A | 4-[2-（Three deuterium methyl of 2- methyl -4--benzene sulfydryl）Phenyl] piperazine hydrobromide novel crystal forms and preparation method | 江苏吉贝尔药业股份有限公司 | 2018-07-31 | — | — | CN | claimed |
| CN-105348641-A | Calcium carbonate filled flame-retardant polypropylene material and preparation method thereof | POLYROCKS CHEMICAL CO LTD | 2016-02-24 | — | — | CN | claimed |
| CN-104974110-A | New crystal form of 1-[2-(2,4-dimethylphenylsulfenyl)phenyl]piperazine hydrobromide, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-10-14 | — | — | CN | claimed |
| CN-104119298-A | Vortioxetine hydrobromide | BEIJING LABWORLD BIO MEDICINE TECHNOLOGY CO LTD | 2014-10-29 | — | — | CN | claimed |
| WO-2014070687-A2 | POLYCATIONIC METHYL PHOSPHOLIPIDS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS | MOLECULAR TRANSFER, INC. (US) | 2014-05-08 | — | — | WO | claimed |
| CN-103113705-A | Transparent cold-resistant flame-retardant polypropylene material and preparation method thereof | POLYROCKS CHEMICAL CO LTD | 2013-05-22 | — | — | CN | claimed |
| CN-102617513-A | 1- [2- (2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 AND 5-HT1A activity for the treatment of cognitive impairment | LUNDBECK & CO AS H | 2012-08-01 | — | — | CN | claimed |
| CN-101671317-B | Preparation method of Naftopidil | BENGBU FENGYUAN TUSHAN PHARMACEUTICAL CO LTD | 2011-04-27 | — | — | CN | claimed |
| CN-101671317-A | Preparation method of Naftopidil | ANHUI BBCA PHARMACEUTICAL CO L | 2010-03-17 | — | — | CN | claimed |
| CN-101472906-A | 1- [ 2- (2, 4-dimethylphenylsulfanyl) -phenyl ] piperazine as a compound with combined serotonin reuptake, 5-HT 3 and 5-HT 1A activity for the treatment of cognitive impairment | LUNDBECK & CO AS H (DK) | 2009-07-01 | — | — | CN | claimed |
| CN-122075428-A | Stable solid preparation | — | 2026-05-26 | — | — | CN | disclosed |
| EP-3166981-B1 | OLIGOSACCHARIDE COMPOSITIONS AND METHODS FOR PRODUCING THEREOF | DSM NUTRITIONAL PRODUCTS LLC (US) | 2026-05-13 | — | — | EP | disclosed |
| US-12514267-B2 | Oligosaccharide compositions for use as animal feed and methods of producing thereof | DSM NUTRITIONAL PRODUCTS, LLC (US) | 2026-01-06 | — | — | US | disclosed |
| EP-0082023-A2 | Thienopyrimidine derivatives, their preparation and their medical use | SANKYO COMPANY LIMITED (JP) | 1983-06-22 | — | — | EP | disclosed |
| US-4189484-A | Antihypertensive quinazoline derivatives | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-02-19 | — | — | US | disclosed |
| US-4001238-A | HYPOTENSIVES | BRISTOL-MYERS COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-4001237-A | HYPOTENSIVES | BRISTOL-MYERS COMPANY (US) | 1977-01-04 | — | — | US | disclosed |