Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 10/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224741 | 1.00 | MET (0.49) | METFGFR1FGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260015 | 0.99 | MET (0.48) | METFGFR1FGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260014 | 0.99 | MET (0.48) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL1225733 | 0.86 | MET (0.44) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL1225734 | 0.86 | MET (0.44) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL260754 | 0.86 | MET (0.67) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL260755 | 0.86 | MET (0.67) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL260141 | 0.86 | AKT2 (0.47) | METFGFR1FGFR2FGFR3AXL | |
| SCHEMBL260140 | 0.86 | AKT2 (0.47) | METFGFR1FGFR2FGFR3AXL | |
| Hydrochloric Acid SCHEMBL260654 | 0.86 | MET (0.44) | METFGFR1FGFR2FGFR3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |