Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 8/20 | 0.60 |
| ▸ | RRM1 | P23921 | 2/20 | 0.54 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CDC25A | P30304 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.50 |
| ▸ | CDC25C | P30307 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12248973 | 0.87 | RRM1 (0.60) | RRM1RRM2BABL1MEN1KMT2A | |
| SCHEMBL12301010 | 0.86 | MEN1 (0.55) | MPLRRM1RRM2BMEN1KMT2A | |
| SCHEMBL12248965 | 0.85 | PARP1 (0.65) | MPLRRM1RRM2BABL1MEN1 | |
| SCHEMBL22728558 | 0.85 | MPL (0.69) | MPLMEN1KMT2ANPC1LMNA | |
| SCHEMBL12249047 | 0.84 | MEN1 (0.59) | MPLMEN1KMT2ANPC1LMNA | |
| SCHEMBL12248874 | 0.81 | SMN1; SMN2 (0.54) | MPLMEN1KMT2ANPC1LMNA | |
| SCHEMBL12248969 | 0.80 | ABL1 (0.70) | RRM1RRM2BABL1MEN1KMT2A | |
| SCHEMBL12249021 | 0.79 | ABL1 (0.69) | MPLRRM1RRM2BABL1MEN1 | |
| SCHEMBL12249005 | 0.78 | RRM1 (0.60) | MPLRRM1RRM2BABL1MEN1 | |
| SCHEMBL11478177 | 0.78 | ABL1 (0.57) | RRM1RRM2BABL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409902-B2 | Modulators of HEC1 activity and methods therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2016-08-09 | — | — | US | disclosed |
| US-20150250794-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORP (TW) | 2015-09-10 | — | — | US | disclosed |
| US-8999983-B2 | Modulators of Hec1 activity and methods therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2015-04-07 | — | — | US | disclosed |
| US-20150057281-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORPORATION (TW) | 2015-02-26 | — | — | US | disclosed |
| US-8946268-B2 | Modulators of HEC1 activity and methods therefor | TAIVEX THERAPEUTICS, INC. (TW) | 2015-02-03 | — | — | US | disclosed |
| US-20130190312-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORPORATION (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20110230486-A1 | Modulators Of HEC1 Activity And Methods Therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190312-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4439/4885RRM1 2048/4885RRM2B 1506/4885 |
| US-20150250794-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4439/4885RRM1 2048/4885RRM2B 1506/4885 |
| US-20150057281-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4500/4885RRM1 2036/4885RRM2B 1503/4885 |
| US-20110230486-A1 | Modulators Of HEC1 Activity And Methods Therefor | WEE1, WEE2, NEK11 | MPL 4500/4885RRM1 2036/4885RRM2B 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.