RRM1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1638485	0.63	7/20
SCHEMBL1639477	0.77	6/20
SCHEMBL1639479	0.77	6/20
SCHEMBL1637574	1.00	5/20
SCHEMBL1637575	1.00	5/20
SCHEMBL1173951	0.65	5/20
SCHEMBL1173953	0.65	5/20
SCHEMBL1639361	0.56	5/20
SCHEMBL1639362	0.56	5/20
SCHEMBL1638800	0.56	5/20
SCHEMBL1639071	0.56	5/20
SCHEMBL800974	0.77	4/20
SCHEMBL1679411	0.77	4/20
SCHEMBL683715	0.76	4/20
SCHEMBL2847708	0.76	4/20
SCHEMBL1639305	0.72	4/20
SCHEMBL1639307	0.72	4/20
SCHEMBL2439831	0.53	4/20
SCHEMBL2439834	0.53	4/20
Orthocresol (SCHEMBL2131451)	0.48	4/20

Clinical trials — most relevant to RRM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
S0720: Adjuvant Therapy Based on Gene Expression in Stage IA and IB Non-Small Cell Lung Cancer	PHASE2	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema	PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Investigating the Effect of Vitamin A Supplementation on Retinitis Pigmentosa	PHASE1	COMPLETED
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC	nan	UNKNOWN
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
LINC00511/miR-185-3p Axis and miR-301a-3p Markers for Breast Cancer Diagnosis	nan	COMPLETED
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
Predictive Study of Radiation Induced Sarcoma	nan	COMPLETED
Diagnosis of Inflammatory Bowel Disease	nan	NOT_YET_RECRUITING
Molecular Genetics of Retinal Degenerations	nan	COMPLETED
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
Improving Genetic Counseling for Patients With Spina Bifida Using Next Generation Sequencing	nan	COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Expression Pattern of HNRNPH1 and HNRNPK Genes in MPNs	nan	UNKNOWN
Clinical Study of Spinal Muscular Atrophy	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Exercise in Ultimate Frisbee Athletes	nan	UNKNOWN
Genetic Factors Affecting the Severity of Beta Thalassemia	nan	COMPLETED
Study of Specimens From Young Patients With Neuroblastoma	nan	COMPLETED
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants	nan	RECRUITING
Role of Genetic Factors in the Development of Lung Disease	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a RRM1 binder may also engage these)

Protein	Name	Similarity
P36602	—	1.000	P36602 →
Q5R919	—	1.000	Q5R919 →
Q03604	—	1.000	Q03604 →
P79732	—	1.000	P79732 →
P07742	—	0.999	P07742 →
P48591	—	0.999	P48591 →
P20503	—	0.998	P20503 →
Q9SJ20	—	0.996	Q9SJ20 →
P21524	—	0.996	P21524 →
P50648	—	0.996	P50648 →
P50647	—	0.995	P50647 →
Q54Q71	—	0.995	Q54Q71 →
P12848	—	0.995	P12848 →
P0DSV2	—	0.994	P0DSV2 →
A0A7H0DN52	—	0.993	A0A7H0DN52 →
P0DSV1	—	0.992	P0DSV1 →
O61065	—	0.992	O61065 →
Q76RD8	—	0.991	Q76RD8 →
P55982	—	0.990	P55982 →
P32282	—	0.990	P32282 →
Q9UW15	—	0.990	Q9UW15 →
P43754	—	0.989	P43754 →
Q89AS4	—	0.988	Q89AS4 →
P21672	—	0.988	P21672 →
P37426	—	0.988	P37426 →
P00452	—	0.987	P00452 →
O15909	—	0.987	O15909 →
Q9ZLF9	—	0.986	Q9ZLF9 →
P28903	—	0.986	P28903 →
Q8K9W3	—	0.984	Q8K9W3 →