Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | CCR6 | P51684 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | TYR | P14679 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2753844 | 0.89 | TYR (0.67) | MPLMAPTPARP1SMN1; SMN2CCR6 | |
| SCHEMBL12248933 | 0.88 | MAPT (0.58) | MPLMAPTPARP1SMN1; SMN2CCR6 | |
| SCHEMBL12248877 | 0.86 | SMN1; SMN2 (0.65) | MPLMAPTSMN1; SMN2CCR6LMNA | |
| SCHEMBL26884271 | 0.85 | PARP1 (0.69) | MPLMAPTPARP1SMN1; SMN2LMNA | |
| SCHEMBL12248431 | 0.85 | MAPT (0.64) | MPLMAPTPARP1SMN1; SMN2CCR6 | |
| SCHEMBL24107494 | 0.85 | ADORA3 (0.64) | MPLMAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL30292491 | 0.85 | ADORA3 (0.64) | MPLMAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL16607206 | 0.85 | MPL (0.68) | MPLMAPTSMN1; SMN2CCR6LMNA | |
| SCHEMBL27986863 | 0.84 | MAPT (0.62) | MPLMAPTPARP1SMN1; SMN2CCR6 | |
| SCHEMBL4875974 | 0.84 | MPL (1.00) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409902-B2 | Modulators of HEC1 activity and methods therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2016-08-09 | — | — | US | disclosed |
| US-20150250794-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORP (TW) | 2015-09-10 | — | — | US | disclosed |
| US-8999983-B2 | Modulators of Hec1 activity and methods therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2015-04-07 | — | — | US | disclosed |
| US-20150057281-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORPORATION (TW) | 2015-02-26 | — | — | US | disclosed |
| US-8946268-B2 | Modulators of HEC1 activity and methods therefor | TAIVEX THERAPEUTICS, INC. (TW) | 2015-02-03 | — | — | US | disclosed |
| US-20130190312-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORPORATION (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20110230486-A1 | Modulators Of HEC1 Activity And Methods Therefor | TAIVEX THERAPEUTICS CORPORATION (TW) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190312-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4439/4885MAPT 2904/4885PARP1 944/4885 |
| US-20150250794-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4439/4885MAPT 2904/4885PARP1 944/4885 |
| US-20150057281-A1 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | WEE1, WEE2, NEK11 | MPL 4500/4885MAPT 2820/4885PARP1 1073/4885 |
| US-20110230486-A1 | Modulators Of HEC1 Activity And Methods Therefor | WEE1, WEE2, NEK11 | MPL 4500/4885MAPT 2820/4885PARP1 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.