Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259211 | 0.80 | ALDH1A1 (0.50) | HTTGAATSHRMAPTKDM4E | |
| SCHEMBL20267430 | 0.79 | GAA (0.73) | HTTGAASMN1; SMN2TSHRHPGD | |
| SCHEMBL11937463 | 0.77 | CNR1 (0.49) | HTTGAASMN1; SMN2TSHRMAPT | |
| SCHEMBL8727474 | 0.73 | TSHR (0.69) | HTTGAASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL7121916 | 0.73 | SMN1; SMN2 (0.77) | HTTGAASMN1; SMN2TSHRHPGD | |
| SCHEMBL28144057 | 0.72 | GAA (0.56) | HTTGAASMN1; SMN2TSHRKDM4E | |
| SCHEMBL1458472 | 0.71 | HTT (0.52) | HTTSMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL70047 | 0.71 | NOTUM (0.65) | GAASMN1; SMN2TSHRMAPTKDM4E | |
| SCHEMBL28133023 | 0.70 | HRH3 (0.55) | GAAMYCKDM4EHPGDALDH1A1 | |
| SCHEMBL4696938 | 0.70 | HPGD (0.72) | HTTSMN1; SMN2TSHRMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |