Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10983501 | 0.86 | ALDH1A1 (0.64) | KMT2APOLBALDH1A1MAPTMEN1 | |
| SCHEMBL18731749 | 0.81 | CYP1A2 (0.58) | POLBALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL1104820 | 0.81 | CYP1A2 (0.62) | POLBALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL28317085 | 0.80 | CYP1A2 (0.56) | KMT2APOLBALDH1A1MAPTMEN1 | |
| Iodide SCHEMBL30847747 | 0.80 | CYP1A2 (0.60) | POLBALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL7468007 | 0.78 | KMT2A (0.60) | KMT2APOLBALDH1A1MAPTMEN1 | |
| SCHEMBL17932284 | 0.77 | CYP1A2 (0.53) | KMT2APOLBALDH1A1MAPTMEN1 | |
| SCHEMBL7610953 | 0.77 | GRM2 (0.58) | KMT2APOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28129147 | 0.77 | CYP1A2 (0.53) | KMT2APOLBALDH1A1MAPTMEN1 | |
| SCHEMBL4816206 | 0.77 | KMT2A (1.00) | KMT2APOLBMAPTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459737-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-29 | — | — | EP | claimed |
| US-8592175-B2 | Nitroreductase enzymatic substrates | bioMérieux, S.A. (FR) | 2013-11-26 | — | — | US | claimed |
| EP-2459737-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | claimed |
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | claimed |
| WO-2011012824-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | claimed |
| EP-2459737-B1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | BIOMERIEUX SA (FR) | 2014-10-29 | — | — | EP | disclosed |
| US-8592175-B2 | Nitroreductase enzymatic substrates | bioMérieux, S.A. (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2459737-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | Biomérieux (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMerieux, SA (FR) | 2012-05-24 | — | — | US | disclosed |
| WO-2011012824-A2 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | bioMérieux (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129204-A1 | NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES | CBR1, CBR3, POR | KMT2A 3575/4885POLB 2150/4885ALDH1A1 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.