Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7258022 | 0.89 | DAO (0.57) | DAORAB9AGAATDP1HTR7 | |
| SCHEMBL875351 | 0.84 | DAO (0.54) | DAORAB9AGAATDP1HTR7 | |
| Hydrochloric Acid SCHEMBL6941257 | 0.82 | DAO (0.53) | DAORAB9AGAATDP1HTR7 | |
| SCHEMBL27680469 | 0.82 | DAO (0.71) | DAORAB9AGAATDP1SMN1; SMN2 | |
| SCHEMBL6899153 | 0.81 | DAO (0.60) | DAORAB9AGAATDP1SMN1; SMN2 | |
| SCHEMBL1149656 | 0.79 | DAO (0.73) | DAORAB9AGAANOTUMPKM | |
| SCHEMBL27680470 | 0.79 | DAO (0.57) | DAORAB9AGAASMN1; SMN2NOTUM | |
| SCHEMBL28943248 | 0.77 | DAO (0.56) | DAORAB9AGAATDP1HTR7 | |
| SCHEMBL12704172 | 0.77 | DAO (0.73) | DAORAB9AGAATDP1SMN1; SMN2 | |
| SCHEMBL1149736 | 0.77 | DAO (0.64) | DAORAB9AGAATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2281822-B1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2013-01-16 | — | — | EP | disclosed |
| EP-2281822-A1 | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2011-02-09 | — | — | EP | disclosed |