Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 18/20 | 0.73 |
| ▸ | EPHB4 | P54760 | 16/20 | 0.73 |
| ▸ | KDR | P35968 | 15/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.73 |
| ▸ | FLT1 | P17948 | 8/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL907216 | 0.91 | EPHA2 (0.87) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL906843 | 0.87 | EPHA2 (0.82) | EPHA2EPHB4KDRERBB2 | |
| SCHEMBL906863 | 0.86 | EPHA2 (0.82) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL907188 | 0.85 | ERBB2 (0.87) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL906792 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL906620 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL13589095 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL13589105 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL12898744 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 | |
| SCHEMBL906898 | 0.84 | EPHA2 (1.00) | EPHA2EPHB4KDRERBB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280003-A2 | Process for preparing receptor-type kinase modulators | Symphony Evolution, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |