Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 17/20 | 0.82 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.82 |
| ▸ | KDR | P35968 | 16/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224168 | 0.90 | EPHA2 (1.00) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL1225752 | 0.87 | EPHA2 (0.73) | EPHA2EPHB4ERBB2KDR | |
| SCHEMBL906863 | 0.86 | EPHA2 (0.82) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL907661 | 0.85 | KDR (1.00) | EPHA2EPHB4ERBB2KDR | |
| SCHEMBL907334 | 0.84 | ERBB2 (1.00) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL14147708 | 0.84 | KDR (0.85) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL1225064 | 0.83 | EPHA2 (0.87) | EPHA2EPHB4ERBB2KDR | |
| SCHEMBL906956 | 0.82 | EPHA2 (1.00) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL907103 | 0.81 | EPHA2 (1.00) | EPHA2EPHB4ERBB2KDREGFR | |
| SCHEMBL906687 | 0.80 | KDR (1.00) | EPHA2EPHB4ERBB2KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277867-A2 | Compounds, pharmaceutical compositions thereof and their use in treating cancer | Symphony Evolution, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |