Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13383267 | 0.86 | AURKA (0.57) | AURKAKMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13383578 | 0.85 | AURKA (0.55) | AURKAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13383723 | 0.85 | AURKA (0.59) | AURKAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL13530674 | 0.81 | KCNQ3 (0.51) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13530697 | 0.78 | HPGD (0.46) | AURKARAB9ANPC1 | |
| SCHEMBL13383683 | 0.76 | GRM5 (0.49) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13383755 | 0.76 | TSHR (0.57) | AURKAALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL13383682 | 0.75 | RXFP1 (0.54) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13383587 | 0.74 | AURKA (0.37) | AURKAALDH1A1PKM | |
| SCHEMBL13530691 | 0.73 | NPC1 (0.44) | AURKAALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-04-23 | — | — | US | disclosed |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-04-23 | — | — | US | disclosed |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-04-23 | — | — | US | disclosed |
| US-8916579-B2 | 5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916579-B2 | 5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-8916579-B2 | 5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-20140296065-A1 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | DOW AGROSCIENCES LLC (IN) | 2014-10-02 | — | — | US | disclosed |
| US-20140296065-A1 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | DOW AGROSCIENCES LLC (IN) | 2014-10-02 | — | — | US | disclosed |
| EP-2462132-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | Dow AgroSciences LLC (US) | 2012-06-13 | — | — | EP | disclosed |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | US | disclosed |
| WO-2011017540-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011017540-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010047866-A2 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | DOW AGROSCIENCES LLC (US) | 2010-04-29 | — | — | WO | disclosed |
| US-20100029482-A1 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | DOW AGROSCIENCES LLC | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029482-A1 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | PFAS, DCTD, MTAP | AURKA 2193/4885KDM4E 879/4885ALDH1A1 1153/4885 |
| US-20140296065-A1 | USE OF 5-FLUOROCYTOSINE AS A FUNGICIDE | PFAS, DCTD, MTAP | AURKA 2193/4885KDM4E 879/4885ALDH1A1 1153/4885 |
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | AURKA 2056/4885KDM4E 699/4885ALDH1A1 528/4885 |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | AURKA 2056/4885KDM4E 699/4885ALDH1A1 528/4885 |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | AURKA 2056/4885KDM4E 699/4885ALDH1A1 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.