Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548362 | 0.84 | BRAF (0.37) | CYP2A6PARP1KDM4ELMNAMAPK1 | |
| SCHEMBL12196947 | 0.76 | PIK3CD (0.37) | CYP2A6PARP1KDM4EGAALMNA | |
| SCHEMBL2505110 | 0.76 | PIK3CD (0.37) | CYP2A6PARP1KDM4EGAALMNA | |
| SCHEMBL12264066 | 0.76 | KDM4E (0.45) | KDM4EGAALMNAMAPK1MAPT | |
| SCHEMBL12265590 | 0.72 | PDE4A (0.39) | KDM4ELMNAMAPK1CCR1CCR5 | |
| SCHEMBL14754848 | 0.71 | BRAF (0.36) | PARP1KDM4EGAALMNAMAPK1 | |
| SCHEMBL108241 | 0.69 | GABRG2 (0.47) | CYP2A6KDM4ELMNAMAPTGSK3B | |
| SCHEMBL21209650 | 0.69 | CYP2A6 (0.47) | CYP2A6KDM4EGAALMNAMAPK1 | |
| SCHEMBL13838190 | 0.67 | GAA (0.34) | PARP1KDM4EGAALMNAMAPK1 | |
| SCHEMBL5765187 | 0.66 | USP7 (0.46) | KDM4EGAAMAPTPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |