Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390466 | 0.82 | RGS12 (0.43) | KCNN4CYP19A1CNR1KIF11SMN1; SMN2 | |
| SCHEMBL2390819 | 0.82 | RGS12 (0.43) | KCNN4CYP19A1CNR1KIF11SMN1; SMN2 | |
| SCHEMBL6369689 | 0.80 | KCNN4 (0.57) | KCNN4CYP3A4CYP3A5CYP19A1HTR2A | |
| SCHEMBL2131459 | 0.80 | CYP3A4 (0.60) | KCNN4CYP3A4CYP3A5CYP19A1HTR2A | |
| SCHEMBL30114522 | 0.80 | CYP3A4 (0.60) | KCNN4CYP3A4CYP3A5CYP19A1HTR2A | |
| SCHEMBL1274088 | 0.80 | KCNN4 (0.50) | KCNN4CYP3A4CYP19A1HTR2AHTR2C | |
| SCHEMBL8542258 | 0.75 | CNR1 (0.44) | CYP19A1CNR1KIF11SMN1; SMN2RGS12 | |
| SCHEMBL675338 | 0.74 | CYP3A4 (0.71) | KCNN4CYP3A4CYP3A5CYP19A1HTR2A | |
| SCHEMBL12264124 | 0.73 | USP2 (0.46) | KCNN4CYP3A4CYP19A1CNR1KIF11 | |
| SCHEMBL4466320 | 0.73 | CYP3A4 (0.56) | KCNN4CYP3A4CYP3A5CYP19A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026263-B2 | Methods for inhibiting neoproliferative changes in blood vessel walls | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026263-B2 | Methods for inhibiting neoproliferative changes in blood vessel walls | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-27 | — | — | US | disclosed |
| US-7235577-B1 | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-06-26 | — | — | US | disclosed |
| US-7235577-B1 | Non-peptide inhibition of T-lymphocyte activation and therapies related thereto | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-06-26 | — | — | US | disclosed |