Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1228111 | 1.00 | HTRA2 (0.55) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1116054 | 0.88 | HTRA2 (0.52) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1116057 | 0.88 | HTRA2 (0.52) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1116267 | 0.85 | HTRA2 (0.57) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1116263 | 0.85 | HTRA2 (0.57) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1227354 | 0.84 | MAPT (0.50) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1227358 | 0.84 | MAPT (0.50) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1228307 | 0.84 | HTRA2 (0.47) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1228304 | 0.84 | HTRA2 (0.47) | HTRA2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL1228154 | 0.83 | HTRA2 (0.49) | HTRA2MAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |