HTRA2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL14932612	0.67	8/20
SCHEMBL14932621	0.65	8/20
SCHEMBL16234096	0.65	8/20
SCHEMBL20235786	0.64	8/20
SCHEMBL14932598	0.62	8/20
SCHEMBL20235804	0.62	8/20
SCHEMBL18162918	0.60	8/20
SCHEMBL21766754	0.60	8/20
SCHEMBL22189219	0.60	8/20
SCHEMBL22189221	0.60	8/20
SCHEMBL20235785	0.60	8/20
SCHEMBL13743299	0.59	8/20
SCHEMBL13743312	0.59	8/20
SCHEMBL15470509	0.59	8/20
SCHEMBL16601591	0.59	8/20
SCHEMBL22882009	0.59	8/20
SCHEMBL14932664	0.58	8/20
SCHEMBL24943566	0.58	8/20
SCHEMBL21128744	0.58	8/20
SCHEMBL12109717	0.58	8/20

Clinical trials — most relevant to HTRA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R	PHASE4	WITHDRAWN
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy	PHASE3	RECRUITING
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin	PHASE2/PHASE3	UNKNOWN
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis	PHASE2	COMPLETED
Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant	PHASE1/PHASE2	RECRUITING
Arginine Replacement Therapy in COVID-19	PHASE2	RECRUITING
Co-transplantation of Mesenchymal Stem Cell Derived Exosomes and Autologous Mitochondria for Patients Candidate for CABG Surgery	PHASE1/PHASE2	UNKNOWN
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
The KHENEREXT Study	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects	PHASE1	COMPLETED
Effectiveness of Light for Enhancement of Cognition by Transcranial Repeated Application (ELECTRA)	EARLY_PHASE1	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Cerebrospinal Fluid Mitochondrial Biomarkers in Ischemic Stroke and Alzheimer Disease	nan	RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions	nan	COMPLETED
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder	nan	COMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Combined Effects of Statins and Exercise on Training Sensitive Health Markers	nan	COMPLETED
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a HTRA2 binder may also engage these)

Protein	Name	Similarity
A0JNK3	—	1.000	A0JNK3 →
Q9JIY5	—	0.990	Q9JIY5 →
D3ZKF5	—	0.977	D3ZKF5 →
Q9QZK5	—	0.975	Q9QZK5 →
B3LVG7	—	0.974	B3LVG7 →
P83110	—	0.973	P83110 →
A2RT60	—	0.973	A2RT60 →
D3ZA76	—	0.972	D3ZA76 →
F1N152	—	0.972	F1N152 →
Q9D236	—	0.972	Q9D236 →
B4G316	—	0.971	B4G316 →
Q297U2	—	0.971	Q297U2 →
B4K835	—	0.971	B4K835 →
HTRA1	Serine protease HTRA1	0.971	landscape →
B3P3J9	—	0.970	B3P3J9 →
B4QZU6	—	0.970	B4QZU6 →
A4IHA1	—	0.969	A4IHA1 →
E1BJW1	—	0.969	E1BJW1 →
B4N937	—	0.969	B4N937 →
B4PST0	—	0.968	B4PST0 →
Q9VFJ3	—	0.968	Q9VFJ3 →
B4JTT7	—	0.968	B4JTT7 →
A6YFB5	—	0.968	A6YFB5 →
B4HEM8	—	0.968	B4HEM8 →
B4LY58	—	0.967	B4LY58 →
Q5XIL0	—	0.965	Q5XIL0 →
P83105	—	0.965	P83105 →
Q9WTZ2	—	0.964	Q9WTZ2 →
B4G2I8	—	0.963	B4G2I8 →
Q852K0	—	0.963	Q852K0 →