Acetic Acid

Acetic Acid

SCHEMBL1228133

CC(=O)[O-].CC(=O)[O-].CCc1cc(CCC(C)C)cc(C=Nc2ccc(N=Cc3cc(CCC(C)C)cc(CC)c3O)cc2)c1O.[Co+2]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.36
ALOX5 P09917 1/20 0.35
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
EGFR P00533 5/20 0.34
ALDH1A1 P00352 5/20 0.33
MAPT P10636 5/20 0.33
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
TDP1 Q9NUW8 3/20 0.33
KDM4E B2RXH2 3/20 0.33
LMNA P02545 2/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CA1 P00915 3/20 0.32
CA2 P00918 3/20 0.32
CA12 O43570 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL1228431 0.94 ALOX5 (0.40) HSP90AA1ALOX5NFKB1NFKB2RELA
Acetic Acid SCHEMBL1229177 0.93 HSP90AA1 (0.36) HSP90AA1ALOX5NFKB1NFKB2RELA
Acetic Acid SCHEMBL1227650 0.91 MAPT (0.37) HSP90AA1ALOX5NFKB1NFKB2RELA
Acetic Acid SCHEMBL1228917 0.88 EGFR (0.36) HSP90AA1EGFRALDH1A1MAPTMEN1
Acetic Acid SCHEMBL1227618 0.88 HSP90AA1 (0.37) HSP90AA1EGFRALDH1A1MAPTMEN1
Acetic Acid SCHEMBL1229846 0.88 ALOX5 (0.38) HSP90AA1ALOX5NFKB1NFKB2RELA
Acetic Acid SCHEMBL1229566 0.87 KDM4E (0.34) HSP90AA1ALOX5NFKB1NFKB2RELA
Acetic Acid SCHEMBL1228949 0.87 ALOX5 (0.36) ALOX5NFKB1NFKB2RELAKDM4E
Acetic Acid SCHEMBL1229130 0.87 ALOX5 (0.36) ALOX5NFKB1NFKB2RELAKDM4E
Acetic Acid SCHEMBL1227754 0.87 CA1 (0.38) HSP90AA1EGFRALDH1A1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110040070-A1 ISOTACTIC POLY(ALKYLENE OXIDE) AND PRODUCTION PROCESS THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-02-17 US disclosed