Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580673 | 1.00 | PIM1 (0.53) | PIM1PIM2NR1H4TTRCISD1 | |
| SCHEMBL1580675 | 1.00 | PIM1 (0.53) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2423162 | 0.99 | PIM1 (0.52) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2423158 | 0.99 | PIM1 (0.52) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2423157 | 0.99 | PIM1 (0.52) | PIM1PIM2NR1H4TTRCISD1 | |
| SCHEMBL13537622 | 0.93 | NR1H4 (0.47) | PIM1PIM2NR1H4TTRCISD1 | |
| SCHEMBL12282336 | 0.82 | PIM1 (0.65) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2424218 | 0.81 | PIM1 (0.64) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2424222 | 0.81 | PIM1 (0.64) | PIM1PIM2NR1H4TTRCISD1 | |
| Hydrochloric Acid SCHEMBL2424216 | 0.81 | PIM1 (0.64) | PIM1PIM2NR1H4TTRCISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-20150051185-A1 | Chemical Compounds 251 | ASTRAZENECA AB (SE) | 2015-02-19 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-8901307-B2 | Chemical compounds 251 | ASTRAZENECA AB (SE) | 2014-12-02 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218182-A1 | CHEMICAL COMPOUNDS 251 | PIM1, PIM3, PIM2 | PIM1 1/4885PIM2 3/4885NR1H4 4583/4885 |
| US-20150051185-A1 | Chemical Compounds 251 | PIM1, PIM3, PIM2 | PIM1 1/4885PIM2 3/4885NR1H4 4579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.