Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.47 |
| ▸ | PIM1 | P11309 | 8/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580673 | 0.93 | PIM1 (0.53) | NR1H4PIM1PIM2PIM3TTR | |
| SCHEMBL1580675 | 0.93 | PIM1 (0.53) | NR1H4PIM1PIM2PIM3TTR | |
| SCHEMBL12281679 | 0.93 | PIM1 (0.53) | NR1H4PIM1PIM2PIM3TTR | |
| Hydrochloric Acid SCHEMBL2423162 | 0.92 | PIM1 (0.52) | NR1H4PIM1PIM2PIM3TTR | |
| Hydrochloric Acid SCHEMBL2423157 | 0.92 | PIM1 (0.52) | NR1H4PIM1PIM2PIM3TTR | |
| Hydrochloric Acid SCHEMBL2423158 | 0.92 | PIM1 (0.52) | NR1H4PIM1PIM2PIM3TTR | |
| SCHEMBL13537641 | 0.84 | PIM1 (0.63) | NR1H4PIM1PIM2PIM3TTR | |
| SCHEMBL13537960 | 0.82 | PIM2 (0.66) | NR1H4PIM1PIM2PIM3 | |
| SCHEMBL13537962 | 0.78 | GPR119 (0.49) | NR1H4PIM1PIM2PIM3PTPN1 | |
| SCHEMBL12282336 | 0.75 | PIM1 (0.65) | NR1H4PIM1PIM2PIM3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |