Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.46 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.46 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.46 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282261 | 0.86 | TTK (0.85) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL2564968 | 0.80 | TTK (1.00) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL2566562 | 0.80 | TTK (0.73) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL2573254 | 0.78 | TTK (0.41) | TTK | |
| SCHEMBL12907318 | 0.75 | TTK (0.66) | TTKAURKA | |
| SCHEMBL2566478 | 0.74 | TTK (0.62) | TTKAURKAITK | |
| SCHEMBL2569868 | 0.71 | TTK (0.90) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL12284538 | 0.70 | TTK (0.84) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL2864993 | 0.70 | TTK (0.51) | TTKAURKBAURKAPLK4CHEK2 | |
| SCHEMBL12281383 | 0.70 | TTK (0.85) | TTKAURKBAURKAPLK4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |