Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565643 | 0.83 | TTK (0.45) | TTKL3MBTL1KMT2AMEN1TDP1 | |
| SCHEMBL2565730 | 0.78 | KMT2A (0.46) | TTKL3MBTL1KMT2AMEN1TDP1 | |
| SCHEMBL12281699 | 0.78 | TTK (0.67) | TTK | |
| SCHEMBL2565605 | 0.74 | TTK (0.49) | TTKL3MBTL1MAPTDGAT2POLB | |
| SCHEMBL5380924 | 0.67 | MAP4K4 (0.40) | L3MBTL1KMT2AMEN1TDP1MAPT | |
| SCHEMBL12282261 | 0.64 | TTK (0.85) | TTK | |
| SCHEMBL5373091 | 0.64 | BACE1 (0.39) | MAPTALDH1A1DGAT2RXRARXRB | |
| SCHEMBL5381394 | 0.64 | IKBKB (0.41) | L3MBTL1KMT2AALDH1A1RORC | |
| SCHEMBL5372575 | 0.63 | MAP4K4 (0.38) | TDP1MAPTKDM4EDGAT2RXRA | |
| SCHEMBL5386995 | 0.62 | MAPT (0.38) | KMT2AMEN1MAPTKCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |