Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 20/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13198198 | 0.85 | AURKA (0.57) | TTK | |
| SCHEMBL2861637 | 0.84 | PDPK1 (0.59) | — | |
| SCHEMBL2582272 | 0.84 | TTK (0.72) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2573333 | 0.83 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL12282273 | 0.81 | TTK (0.66) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL5373102 | 0.81 | PIM1 (0.59) | TTK | |
| SCHEMBL2563660 | 0.81 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2570870 | 0.81 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL30725877 | 0.80 | CDK7 (0.67) | — | |
| SCHEMBL29172495 | 0.80 | CDK7 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |