Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1228296 | 1.00 | HTRA2 (0.49) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1228155 | 0.92 | HTRA2 (0.49) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1228154 | 0.92 | HTRA2 (0.49) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1116267 | 0.92 | HTRA2 (0.57) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1116263 | 0.92 | HTRA2 (0.57) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1227354 | 0.91 | MAPT (0.50) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1227358 | 0.91 | MAPT (0.50) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1228130 | 0.89 | HTRA2 (0.50) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1228131 | 0.89 | HTRA2 (0.50) | HTRA2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1226763 | 0.89 | HTRA2 (0.54) | HTRA2MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |