Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.62 |
| ▸ | ADK | P55263 | 6/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16330666 | 0.91 | HIF1A (0.65) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330670 | 0.89 | HIF1A (0.65) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330668 | 0.88 | HIF1A (0.66) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL12284350 | 0.87 | TP53 (0.56) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330669 | 0.86 | HIF1A (0.59) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330722 | 0.84 | HIF1A (0.65) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330675 | 0.83 | HIF1A (0.64) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330723 | 0.83 | HIF1A (0.63) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL14616896 | 0.82 | HIF1A (0.72) | HIF1APAX8ADKTMEM97SIGMAR1 | |
| SCHEMBL16330765 | 0.82 | HIF1A (0.54) | HIF1APAX8ADKTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130599-A1 | POLYMERIC CONJUGATES OF ADENINE NUCLEOSIDE ANALOGS | ENZON PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |