SCHEMBL12284278

SCHEMBL12284278

NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)Cc4ccccn4)cc23)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTK P33981 18/20 1.00
AURKB Q96GD4 3/20 0.62
PLK4 O00444 2/20 0.62
CHEK2 O96017 2/20 0.62
CYP3A4 P08684 2/20 0.62
CYP2C9 P11712 2/20 0.62
CA1 P00915 1/20 0.60
CA2 P00918 1/20 0.60
CA5A P35218 1/20 0.60
CA7 P43166 1/20 0.60
CA5B Q9Y2D0 1/20 0.60
AURKA O14965 2/20 0.58
CYP1A1 P04798 1/20 0.58
CYP1A2 P05177 1/20 0.58
CYP2E1 P05181 1/20 0.58
CYP2C8 P10632 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2A6 P11509 1/20 0.58
CYP4B1 P13584 1/20 0.58
CYP2B6 P20813 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2569400 0.88 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12282318 0.85 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12281036 0.85 TTK (0.80) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2564968 0.84 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2564623 0.83 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12284538 0.83 TTK (0.84) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2588127 0.83 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2567560 0.83 TTK (0.83) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12282143 0.82 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2571823 0.82 TTK (0.78) TTKAURKBPLK4CHEK2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011123937-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORK (CA) 2011-10-13 WO disclosed