Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 19/20 | 1.00 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12281383 | 0.92 | TTK (0.85) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL12282318 | 0.87 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2861303 | 0.86 | TTK (0.75) | TTKAURKB | |
| SCHEMBL2569400 | 0.86 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2571823 | 0.85 | TTK (0.78) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2570870 | 0.85 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL12281036 | 0.85 | TTK (0.80) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL12284278 | 0.83 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL12284538 | 0.83 | TTK (0.84) | TTKPLK4CHEK2CYP3A4CYP2C9 | |
| SCHEMBL2564623 | 0.83 | TTK (1.00) | TTKPLK4CHEK2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |