Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 8/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12285123 | 0.91 | PTGES (0.54) | PTGESMAPTLMNATP53MEN1 | |
| SCHEMBL12284788 | 0.90 | PTGES (0.57) | PTGESGRIK1GRIK2MAPTTP53 | |
| SCHEMBL12284817 | 0.89 | PTGES (0.57) | PTGESMAPTTP53MEN1KMT2A | |
| SCHEMBL12284791 | 0.88 | PTGES (0.68) | PTGESMAPTTP53HTTALDH1A1 | |
| SCHEMBL12285128 | 0.88 | PTGES (0.53) | PTGESGRIK1GRIK2MAPTTP53 | |
| SCHEMBL12285129 | 0.86 | PTGES (0.59) | PTGESMAPTTP53RAB9ACHRM5 | |
| SCHEMBL12285144 | 0.86 | PTGES (0.58) | PTGESMAPTLMNATP53KDM4E | |
| SCHEMBL12284921 | 0.85 | PTGES (0.53) | PTGESMAPTTP53MEN1KMT2A | |
| SCHEMBL12285020 | 0.85 | PTGES (0.56) | PTGESMAPTTP53RAB9ACHRM5 | |
| SCHEMBL12284815 | 0.83 | KCNK3 (0.52) | PTGESMAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017644-B2 | 2-arylindole derivatives as nPGES-1 inhibitors | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-09-13 | — | — | US | disclosed |
| US-8017644-B2 | 2-arylindole derivatives as nPGES-1 inhibitors | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-09-13 | — | — | US | disclosed |
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2009-07-23 | — | — | US | disclosed |
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186922-A1 | 2-ARYLINDOLE DERIVATIVES AS NPGES-I INHIBITORS | PTGES, NAT1, CSNK1G2 | PTGES 1/4885GRIK1 1260/4885GRIK2 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.