Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | FPR1 | P21462 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.39 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621651 | 1.00 | PPARA (0.45) | PPARAFPR1NOTUMKDM5AKDM4C | |
| SCHEMBL2621650 | 1.00 | PPARA (0.45) | PPARAFPR1NOTUMKDM5AKDM4C | |
| SCHEMBL12182713 | 0.81 | FPR1 (0.35) | PPARAFPR1SLC2A1SLC2A2SLC2A3 | |
| SCHEMBL2621695 | 0.81 | PDPK1 (0.46) | FPR1KDM5BSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL2621694 | 0.81 | PDPK1 (0.46) | FPR1KDM5BSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL12285714 | 0.81 | PDPK1 (0.46) | FPR1KDM5BSLC2A1SLC2A2SLC2A3 | |
| SCHEMBL2621648 | 0.78 | KDM5A (0.43) | NOTUMKDM5AKDM4CKDM5BKCNK3 | |
| SCHEMBL12285807 | 0.78 | KDM5A (0.43) | NOTUMKDM5AKDM4CKDM5BKCNK3 | |
| SCHEMBL2621649 | 0.78 | KDM5A (0.43) | NOTUMKDM5AKDM4CKDM5BKCNK3 | |
| SCHEMBL680255 | 0.78 | PPARA (0.54) | PPARANOTUMGAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560967-B1 | Heterocyclic carboxylic acid amides as PDK1 inihibitors | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |
| WO-2011131741-A1 | HETEROCYCLIC CARBOXYLIC ACID AMIDES AS PDK1 INIHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-27 | — | — | WO | disclosed |