Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559492 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2557601 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2553916 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL12290020 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2553847 | 0.72 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL18711653 | 0.72 | MAPT (0.76) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2557594 | 0.72 | MAPK1 (0.77) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2556930 | 0.72 | MAPT (0.81) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL12288921 | 0.71 | RAB9A (1.00) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL2557793 | 0.71 | RAB9A (1.00) | SMN1; SMN2RAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | disclosed |