Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.57 |
| ▸ | CBFB | Q13951 | 13/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | METAP2 | P50579 | 5/20 | 0.52 |
| ▸ | METAP1 | P53582 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906659 | 0.95 | NPC1 (0.54) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12287688 | 0.94 | NPC1 (0.53) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892659 | 0.90 | NPC1 (0.49) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL20362404 | 0.90 | NPC1 (0.51) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892431 | 0.84 | NPC1 (0.46) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12289543 | 0.81 | CBFB (0.50) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12287556 | 0.79 | NPC1 (0.54) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL13866538 | 0.77 | NPC1 (0.74) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892370 | 0.76 | NPC1 (0.49) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12287509 | 0.75 | CBFB (0.60) | NPC1RAB9ARUNX1CBFBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556058-B1 | RADIOPROTECTOR COMPOUNDS AND METHODS | PETER MACCALLUM CANCER INST (AU) | 2017-06-14 | — | — | EP | disclosed |
| WO-2011123890-A1 | RADIOPROTECTOR COMPOUNDS AND METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2011-10-13 | — | — | WO | disclosed |