Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.54 |
| ▸ | CBFB | Q13951 | 13/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 6/20 | 0.49 |
| ▸ | METAP1 | P53582 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12289529 | 0.95 | NPC1 (0.57) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892659 | 0.95 | NPC1 (0.49) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL20362404 | 0.94 | NPC1 (0.51) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12287688 | 0.90 | NPC1 (0.53) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892431 | 0.90 | NPC1 (0.46) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL12289543 | 0.86 | CBFB (0.50) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892370 | 0.81 | NPC1 (0.49) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL14892594 | 0.77 | ALDH1A1 (0.43) | NPC1RAB9ACBFBKDM4ESMN1; SMN2 | |
| SCHEMBL12287556 | 0.77 | NPC1 (0.54) | NPC1RAB9ARUNX1CBFBKDM4E | |
| SCHEMBL20362424 | 0.77 | CBFB (0.55) | NPC1RAB9ARUNX1CBFBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46943-E1 | Radioprotector compounds and methods | PETER MACCALLUM CANCER INSTITUTE (AU) | 2018-07-10 | — | — | US | disclosed |
| US-8999993-B2 | Radioprotector compounds and methods | PETER MACCALLUM CANCER INSTITUTE (AU) | 2015-04-07 | — | — | US | disclosed |
| US-20130109678-A1 | RADIOPROTECTOR COMPOUNDS AND METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109678-A1 | RADIOPROTECTOR COMPOUNDS AND METHODS | NR1H2, NR1H3, NR1I3 | NPC1 230/4885RAB9A 2599/4885RUNX1 1316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.