Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 18/20 | 0.57 |
| ▸ | ARG2 | P78540 | 18/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894833 | 0.89 | ARG1 (0.62) | ARG1ARG2SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL895320 | 0.88 | ARG1 (0.61) | ARG1ARG2SMN1; SMN2ALDH1A1 | |
| SCHEMBL12292283 | 0.87 | ARG1 (0.60) | ARG1ARG2 | |
| SCHEMBL895982 | 0.82 | ARG1 (0.82) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL894450 | 0.81 | ARG1 (0.81) | ARG1ARG2 | |
| SCHEMBL895483 | 0.80 | ARG1 (0.61) | ARG1ARG2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL895016 | 0.80 | ARG1 (0.60) | ARG1ARG2SMN1; SMN2 | |
| SCHEMBL893860 | 0.79 | ARG1 (0.77) | ARG1ARG2 | |
| SCHEMBL12293970 | 0.79 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL895591 | 0.79 | ARG1 (0.73) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133653-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED (US) | 2011-10-27 | — | — | WO | disclosed |