ARG1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL894204	0.71	20/20
Hydrochloric Acid (SCHEMBL894177)	0.56	20/20
Hydrochloric Acid (SCHEMBL894179)	0.56	20/20
SCHEMBL893861	1.00	19/20
SCHEMBL893919	1.00	19/20
SCHEMBL894176	1.00	19/20
Hydrochloric Acid (SCHEMBL893814)	0.97	19/20
SCHEMBL893860	0.77	19/20
SCHEMBL894055	0.76	19/20
SCHEMBL894172	0.74	19/20
Hydrochloric Acid (SCHEMBL894195)	0.73	19/20
SCHEMBL894159	0.71	19/20
SCHEMBL893946	0.69	19/20
SCHEMBL893947	0.69	19/20
Hydrochloric Acid (SCHEMBL894185)	0.69	19/20
SCHEMBL894054	0.67	19/20
SCHEMBL893976	0.66	19/20
SCHEMBL894122	0.64	19/20
SCHEMBL894088	0.63	19/20
SCHEMBL893767	0.63	19/20

Clinical trials — most relevant to ARG1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study	PHASE4	COMPLETED
Study of Arginine Free IED in Critically Ill Patients.	PHASE4	COMPLETED
Nutrition Therapy in Improving Immune System in Patients With Bladder Cancer That Can Be Removed by Surgery	PHASE3	ACTIVE_NOT_RECRUITING
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial	PHASE3	COMPLETED
Vascular Function Intervention Trial in Sickle Cell Disease	PHASE2/PHASE3	UNKNOWN
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma	PHASE2	COMPLETED
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial	PHASE2	COMPLETED
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients	PHASE2	COMPLETED
The High-Dose Aldesleukin (IL-2) Select Trial for Patients With Metastatic Renal Cell Carcinoma	PHASE2	COMPLETED
Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors	PHASE1	COMPLETED
Arginase Inhibition in Ischemia-reperfusion Injury	PHASE1	COMPLETED
Effects of Heme Arginate in Healthy Male Subjects	PHASE1	COMPLETED
The Effect of Sodium Nitrite on Renal Function and Blood Pressure in Hypertensive Versus Healthy Subjects	PHASE1	UNKNOWN
Arginase Inhibition in Humans With Obesity	EARLY_PHASE1	COMPLETED
Arginase Inhibition in Type 1 and Type 2 Diabetes Mellitus	nan	COMPLETED
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes	nan	UNKNOWN
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Preterm Arginine INTake Study	nan	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Role of Nitric Oxide in Malaria	nan	COMPLETED
Perioperative Immunonutrition in Patients Undergoing Gynecologic or General Elective Surgery (PURPOSE)	nan	COMPLETED
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)	nan	RECRUITING
Study of Arginine and Nitric Oxide in Patients With Diabetes	nan	COMPLETED
HIIT and MICT on Nitric Oxide-mediated Erythrocyte Rheology	nan	UNKNOWN
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload)	nan	UNKNOWN
Glucagon Like Peptide-1 in Remote Ischemic Conditioning	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ARG1 binder may also engage these)

Protein	Name	Similarity
Q95JC8	—	1.000	Q95JC8 →
Q2KJ64	—	1.000	Q2KJ64 →
P07824	—	1.000	P07824 →
Q61176	—	1.000	Q61176 →
Q95KM0	—	1.000	Q95KM0 →
P49900	—	0.998	P49900 →
ARG2	Arginase-2, mitochondrial	0.995	landscape →
O08701	—	0.994	O08701 →
P30759	—	0.994	P30759 →
O08691	—	0.990	O08691 →
Q91554	—	0.989	Q91554 →
Q58DL1	—	0.988	Q58DL1 →
A0A2R2JFW7	—	0.986	A0A2R2JFW7 →
Q91553	—	0.984	Q91553 →
Q12611	—	0.984	Q12611 →
Q4VK78	—	0.984	Q4VK78 →
Q91555	—	0.981	Q91555 →
P00812	—	0.981	P00812 →
P39138	—	0.981	P39138 →
Q6CLS8	—	0.979	Q6CLS8 →
P37818	—	0.979	P37818 →
Q1E180	—	0.978	Q1E180 →
P40906	—	0.977	P40906 →
Q10066	—	0.976	Q10066 →
P33280	—	0.976	P33280 →
Q7M0Z3	—	0.974	Q7M0Z3 →
Q9VR81	—	0.972	Q9VR81 →
C6C0A2	—	0.972	C6C0A2 →
Q42954	—	0.972	Q42954 →
Q8R0X7	—	0.971	Q8R0X7 →