Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20241721 | 0.82 | PIK3CA (0.42) | JAK2TYK2HRH4CYP2C19PIK3CA | |
| SCHEMBL25142286 | 0.82 | JAK2 (0.47) | JAK2TYK2HRH4CYP2C19PIK3CA | |
| SCHEMBL12295201 | 0.81 | JAK2 (0.39) | PIM1PIM3PIM2JAK2TYK2 | |
| SCHEMBL14872324 | 0.81 | HRH4 (0.50) | PIM1PIM3PIM2JAK2TYK2 | |
| SCHEMBL14868457 | 0.81 | HRH4 (0.43) | PIM1PIM3PIM2JAK2TYK2 | |
| SCHEMBL19703397 | 0.78 | GRIN2D (0.46) | PIM1PIM3PIM2JAK2TYK2 | |
| SCHEMBL10272311 | 0.77 | CYP2C19 (0.63) | HRH4CYP2C19CYP1A2ALDH1A1CYP2C9 | |
| Hydrochloric Acid SCHEMBL27503702 | 0.75 | HRH4 (0.41) | HRH4CYP1A2LRRK2P4HTM | |
| SCHEMBL12497703 | 0.75 | HRH4 (0.57) | HRH4CYP2C19CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL11981553 | 0.75 | SMN1; SMN2 (0.50) | HRH4CYP2C19ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |