Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.47 |
| ▸ | TYK2 | P29597 | 12/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | PI4KA | P42356 | 3/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372437 | 0.87 | JAK2 (0.47) | JAK2TYK2GSK3BCSF1R | |
| SCHEMBL2372127 | 0.86 | TYK2 (0.63) | JAK2TYK2GSK3B | |
| SCHEMBL2372641 | 0.86 | JAK2 (0.49) | JAK2TYK2GSK3BPI4KAPI4K2B | |
| SCHEMBL2372153 | 0.84 | CHEK1 (0.48) | JAK2TYK2GSK3B | |
| SCHEMBL2372387 | 0.83 | JAK2 (0.45) | JAK2TYK2GSK3BCSF1R | |
| SCHEMBL2372667 | 0.82 | JAK2 (0.44) | JAK2TYK2GSK3BCSF1R | |
| SCHEMBL2371831 | 0.82 | JAK2 (0.41) | JAK2TYK2GSK3BCSF1R | |
| SCHEMBL2372281 | 0.81 | TYK2 (0.51) | JAK2TYK2GSK3BCSF1R | |
| SCHEMBL2371230 | 0.81 | GSK3B (0.51) | JAK2TYK2GSK3B | |
| SCHEMBL2372379 | 0.80 | PTGES (0.42) | JAK2TYK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011113802-A2 | IMIDAZOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-22 | — | — | WO | disclosed |